This article lists the descendants of James VI and I, King of Scotland and England.
- 20. James VI and I, King of Scotland and England (1566-1625)
- -----21. Henry Frederick Stuart (1594-1612)
- -----21. Charles I, King of England (1600-1649)
- -----+ m. Henriette Maria de Bourbon (1606-1669)
- ----------22. Charles James Stuart (?-1629)
- ----------22. Charles II, King of England (1630-1685)
- ----------+ m. Catherine de Braganza (1638-1705)
- ----------+ c. Lucy Walter
- ---------------23. James Croft, Duke of Monmouth (1649-1685)
- ---------------+ m. Anne Scott (1651-1732)
- --------------------24. Charles Scott (1672-1674)
- --------------------24. James Scott, Earl of Doncaster (1674-1705)
- --------------------+ m. Henrietta Hyde (?-1730)
- -------------------------25. Francis Scott, 2nd Duke of Buccleuch (1694-1751)
- -------------------------+ m. Caroline Campbell (1717-1794)
- ------------------------------26. John Scott (1745-1749)
- ------------------------------26. Henry Scott, 3rd Duke of Buccleuch (1746-1812)
- ------------------------------+ m. Elizabeth Montagu (?-1827)
- -----------------------------------27. George Scott (?-1768)
- -----------------------------------27. Charles William Henry Montagu-Scott, 4th Duke of Buccleuch, 6th Duke of Queensberry (1772-1819)
- -----------------------------------+ m. Harriet Catharine Townshend (1773-1814)
- ----------------------------------------28. George Henry Montagu-Scott (1798-1803)
- ----------------------------------------28. Walter Francis Montagu-Scott (1806-1884)
- ----------------------------------------+ m. Louisa Jane Hamilton (?-1912)
- ---------------------------------------------29. William Henry Montagu-Douglas-Scott (1831-1941)
- --------------------------------------------------30. Walter Henry Montagu-Douglas-Scott (1861-1886)
- --------------------------------------------------30. John Charles Montagu-Douglas-Scott (1864-1935)