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|Possible time of origin||unknown|
|Possible place of origin||Western Eurasia|
|Defining mutations||none, CRS is in haplogroup H|
The Cambridge Reference Sequence (CRS), the human mitochondrial sequence to which all other sequences are compared, belongs to haplogroup H.
About one half of Europeans are of mt-DNA haplogroup H. The haplogroup is also common in North Africa and the Middle East.  According to FamilyTreeDNA , currently the largest genetic genealogy testing firm, approximately 32% of the their database is haplogroup H. Of those H results, approximately 21% of them has a 519C mutation, which is volatile and generally not useful in characterizing subclades. The 4336 tRNA nucleotide position variant in haplogroup H has been shown to be associated with late-onset Alzheimer's disease.
Relationship to other haplogroupsEdit
Haplogroup H is a descendant of haplogroup HV.
- Haplogroup L1
|most recent common mt-ancestor|
Haplogroup H is divided into various subclades.
- Haplogroup H
People in haplogroup H Edit
(Note: The below list is an incredibly tiny and unrepresentative sampling, as nearly 1 of 2 Europeans share this haplogroup)
Marie Antoinette, and her matrilineal ancestors back to Bertha von Putelendorf (died 1190), were of haplogroup H. (Jehaes et al, European Journal of Human Genetics, vol 6, pp. 383-395 (1998) and vol 9, pp. 185-190, (2001): the extended sequence is: HVR1 T16519C; HVR2 T152C, C194T, A263G and N315.1C.) If all pedigrees are assumed correct, the following other matrilineal relatives of Marie Antoinette were of haplogroup H: Maria Theresa of Austria, Marie-Louise of Austria (second wife of Napoleon Bonaparte), Peter II of Russia, Pedro II of Brazil, Philip III, Leopold II of Belgium, Frederick William II of Prussia, Ferdinand I of Bulgaria, Victor Emmanuel II of Italy, August III the Saxon, and Stanisław August Poniatowski. 
Empress Alexandra FyodorovnaEdit
Among other famous members of group H are Empress Alexandra Fyodorovna, wife of the last Russian tsar Nicholas II, and all of her children. Their membership in haplogroup H was established when genetic testing was done on their remains to authenticate their identity.
As a consequence, all of relatives on the matrilineal line also have this haplogroup. These include Alexandra Fyodorovna's relatives along the matrilineal line all the way back to her ancestor Blanca Núñez de Lara (approx. 1317 – 1347), which include her grandmother Queen Victoria and her cousins the Duke of Edinburgh, Lord Mountbatten, and Wilhelm II of Germany and his wife Augusta Viktoria of Schleswig-Holstein. Other matrilineal descendants of Blanca Núñez de Lara include Marie de' Medici, Anne of Austria, Charles II, James II, and William III of England, Leopold I of Belgium, Wladislaus IV and John II of Poland, Michael I of Romania, George II, Alexander I, Paul and Constantine II of Greece, Christian VI of Denmark, Louis XIII, Louis XV and Louis XIV of France, Charles XI, and Christina of Sweden, William I of the Netherlands, Philip V, Philip IV, and Charles II of Spain and Queen Sophia of Spain. .
- ^ Atlas of the Human Journey - The Genographic Project
- ^ http://www.familytreedna.com/
- ^ 
- ^ "Coming Home: Susan Sarandon". BBC Wales. 29 November 2006. http://www.bbc.co.uk/wales/southeast/sites/bridgend/pages/susansarandon.shtml. Retrieved 2006-12-03.
- Spread of Haplogroup H, from National Geographic
- Disuniting Uniformity: A Pied Cladistic Canvas of mtDNA Haplogroup H in Eurasia
- Hope The H1 mtDNA Haplogroup Project
- Backbone of the phylogenetic tree of the mtDNA Haplogroup H sub-clades
- What does my H subclade mean?
- Haplogroup and Subcluster Frequencies for European Populations
- Danish Demes Regional DNA Project: mtDNA Haplogroup H
|This page uses content from the English language Wikipedia. The original content was at Haplogroup H (mtDNA). The list of authors can be seen in the page history. As with this Familypedia wiki, the content of Wikipedia is available under the Creative Commons License.|