Located on the banks of Mandagery Creek in the heart of a farming community, it is the home of the Manildra Flour Mill (largest in the Southern Hemisphere) which commenced in 1952 and has since expanded into the largest industrial wheat producer in Australia. The Manildra Flour Mill is owned by The Manildra Group, who export to the world. The Manildra royal Hotel (1912) is one of 3 pubs in the town.
Historically, it is the home of the oldest running cinema in Australia which was originally a travelling attraction (since 1923) that found a home and has been offering entertainment ever since. This cinema is called the Amusu (pronounced 'amuse you') Theatre, and movies are screened every fortnight.
The name Manildra is an aboriginal word meaning 'winding river'. It is said the town was called this because of Mandagery Creek, which winds around Manildra's east side.