She was a granddaughter of Ephraim Jackson (1658-1731), an early Quaker settler from Great Eccleston in Lancashire, to Bucks County in PA as an indentured servant to the Hall family from Macclesfield in Cheshire. Susanah married John Jackson (1746-1795) a grandson of another Quaker pioneer to Chester County PA, Isaac Jackson (1665-1750), from Ballitore in Ireland who arrived in America in 1725. John's family fled to the Pennfield Colony in Charlotte County, New Brunswick, Canada in 1783-1788, after his property had been confiscated due to his British Loyalist sympathies. After the birth of their youngest son Thomas in 1788 (an event recorded in the birth list for the New Garden PA Quaker Monthly Meeting), they returned to what had become the USA, to the Gunpowder MM in MD, and after John the father died, the family fragmented and were last recorded in Quaker records as having gone to the Kennett MM in December, 1799.