U.S. Congressman and Senator Thomas Willis Cobb was born in Columbia County, Georgia in 1784, son of John Cobb (1757-1797) and Elizabeth Beckham, natives of Virginia. Cobb pursued the study of law, was admitted to the bar amd began his law practice in Lexington, Oglethorpe County, Georgia. He later moved to Greensboro, Greene County, Georgia where he was elected a Representative to the 15th, 16th and 18th Congresses, serving from March 4, 1817 to March 3, 1821 and again from March 4, 1823 to December 6, 1824, when he resigned, having been elected to the U.S. Senate, serving from December 6, 1824, until his resignation in 1828. He died in Greensboro, Georgia on February 1, 1830 and is buried in the Greensboro City Cemetery, Greene County, Georgia.

He married Mary W. Moore (c1784-1826) and together they raised a family of six children, including: Mary, Lewis, Joseph, John, Catherine and William.